These papers cleared peer review. Here’s what a reviewer could have caught in minutes.
Each gallery runs a curated set of high-impact papers — and a few that were later retracted — through the Αlpha¹ Rigor Review engine. We don’t predict retractions. We surface specific, verifiable problems: statistics recomputed, every data & code link probed live, references checked against the retraction record. On papers later retracted, those problems were in the text all along.
Clinical Trials — Solid-Tumor Oncology
Randomized clinical trials in solid-tumor cancers (breast, lung, colorectal, prostate, renal, gastric, pancreatic, nasopharyngeal), from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Cardiovascular
Randomized clinical trials in hypertension, heart failure, acute coronary syndromes, CABG, and atrial fibrillation / vascular disease, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Metabolic & Endocrine
Randomized clinical trials in obesity, diabetes, and lipid disorders (GLP-1 / tirzepatide, SGLT2, dyslipidemia), from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Infectious Disease (Treatment)
Randomized clinical trials in treatment of infection — TB, HIV, COVID-19, gonorrhoea, syphilis, plague, mpox, hepatitis B, scabies, dengue, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Vaccines & Prevention
Randomized clinical trials in vaccines and prophylaxis — malaria, BCG/TB, polio, typhoid, yellow fever, Lassa, and vector control, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Neurology & Psychiatry
Randomized clinical trials in stroke, hydrocephalus, Huntington's, myasthenia gravis, ADHD, autism, self-harm, and insomnia, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Respiratory
Randomized clinical trials in pulmonary disease — idiopathic pulmonary fibrosis, neonatal ventilation, pneumonia, and lung-nodule diagnosis, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Clinical Trials — Obstetrics, Reproductive & Neonatal
Randomized clinical trials in pregnancy, fertility, and newborn care (gestational diabetes, postpartum haemorrhage, IVF, breastfeeding, neonatal care), from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.
Alpha1 Selection
Every preprint we surface in the Alpha1 Selection, run through the Αlpha¹ Rigor Review engine.