Clinical Trials — Infectious Disease (Treatment)

Draft review set — treatment of infection — TB, HIV, COVID-19, gonorrhoea, syphilis, plague, mpox, hepatitis B, scabies, dengue. Each card leads with the engine's verdict; open any to read the full report before publishing.

Randomized clinical trials in treatment of infection — TB, HIV, COVID-19, gonorrhoea, syphilis, plague, mpox, hepatitis B, scabies, dengue, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.

1 of these papers was later retracted. Look for the red RETRACTEDband — then read what the engine flagged in the original published text, before any retraction notice.

2Reviewed

1Pass

1Warn

0Critical

Sort

Retracted

Observational0/7Action Items · Critical / High

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Mehra MR, Desai SS, Ruschitzka F, Patel AN.

WARNScore 66

Conclusions

9 supported · 3 partial of 12

8 Rigor Dimensions

3 of 8 pass · 4 warn · 1 fail

Verified

stats consistent

3 Αlpha¹ Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Alpha1 corpus · verify findings

Read paperDOI Open record

Interventional0/4Action Items · Critical / High

Zoliflodacin versus ceftriaxone plus azithromycin for treatment of uncomplicated urogenital gonorrhoea: an international, randomised, controlled, open-label, phase 3, non-inferiority clinical trial

Luckey A, Balasegaram M, Barbee LA, et al. (Zoliflodacin Phase 3 Study Group)

PASSScore 94

Conclusions

6 supported · 3 partial of 9

8 Rigor Dimensions

8 of 8 pass

Verified

3/3 links livestats consistentregistered

3 Αlpha¹ Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Alpha1 corpus · verify findings

Read paperDOI Open record

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How to read this.The engine surfaces specific, verifiable rigor problems — it does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.