Clinical Trials — Neurology & Psychiatry

Draft review set — stroke, hydrocephalus, Huntington's, myasthenia gravis, ADHD, autism, self-harm, and insomnia. Each card leads with the engine's verdict; open any to read the full report before publishing.

Randomized clinical trials in stroke, hydrocephalus, Huntington's, myasthenia gravis, ADHD, autism, self-harm, and insomnia, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.

1Reviewed

0Pass

1Warn

0Critical

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Interventional0/8Action Items · Critical / High

A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus

Luciano MG, Williams MA, Hamilton MG, et al. (PENS Trial Investigators)

WARNScore 94

Conclusions

8 supported · 2 partial of 10

8 Rigor Dimensions

5 of 8 pass · 3 warn

Verified

2/3 links livestats consistentregistered

3 Αlpha¹ Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Alpha1 corpus · verify findings

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How to read this.The engine surfaces specific, verifiable rigor problems — it does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.