Clinical Trials — Vaccines & Prevention

Draft review set — vaccines and prophylaxis — malaria, BCG/TB, polio, typhoid, yellow fever, Lassa, and vector control. Each card leads with the engine's verdict; open any to read the full report before publishing.

Randomized clinical trials in vaccines and prophylaxis — malaria, BCG/TB, polio, typhoid, yellow fever, Lassa, and vector control, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026) — reviewed by the Αlpha¹ Rigor Review engine for rigor & reproducibility.

1Reviewed

1Pass

0Warn

0Critical

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Interventional0/3Action Items · Critical / High

Safety and efficacy of the monoclonal antibody L9LS for malaria prevention in children exposed to perennial malaria transmission in Kenya: a randomised, double-blind, placebo-controlled, phase 2 trial

Steinhardt LC, Kwambai TK, Oneko M, et al. (Kenya Malaria mAb Trials Team)

PASSScore 67

Conclusions

9 supported · 3 partial of 12

8 Rigor Dimensions

7 of 8 pass · 1 warn

Verified

stats consistentregistered

3 Αlpha¹ Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Alpha1 corpus · verify findings

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How to read this.The engine surfaces specific, verifiable rigor problems — it does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.