PASSReviewer 1· 70% conf
Methods are detailed, the trial is registered (NCT04110340), all pre-specified outcomes including negative secondary results are reported, limitations are discussed, and funding is disclosed; CONSORT adherence and an explicit COI statement are not stated.
Evidence
paraphrase[Abstract; Methods]
“Trial registration number: NCT04110340”direct quote[Funding]
“This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome [216273/Z/19/Z]”direct quote[Discussion]
“an endpoint of treatment failure at Day 11 that included an additional component for failure of <25% reduction in bubo size was inferior in a comparative analysis, however this composite measure of treatment failure is not considered clinically meaningful”PASSReviewer 2· 80% conf
Methods are detailed, the trial is registered (NCT04110340), outcomes including negative ones are reported, limitations are thoroughly discussed, and conclusions are proportional. Gaps: no explicit CONSORT reference and no conflicts-of-interest statement.
Evidence
direct quote[Abstract]
“Trial registration number : NCT04110340”direct quote[Discussion, paragraph 2]
“However, patient’s adherence to the prescribed regimen might be higher in the trial than in practice as all cases were hospitalised for the first three days of treatment”direct quote[Funding]
“This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome [216273/Z/19/Z].”PASSReviewer 3· 85% conf
Methods are complete, trial registration is reported, limitations are discussed, and conclusions are proportional. However, no reporting guideline is referenced, and a conflict of interest statement is missing.
Evidence
direct quote[Abstract, Methods]
“Trial registration number : NCT04110340”direct quote[Discussion, paragraph 4]
“However, patient’s adherence to the prescribed regimen might be higher in the trial than in practice as all cases were hospitalised for the first three days of treatment and were subsequently seen daily by village health workers, which might not be routine practice.”direct quote[Funding section]
“This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome [216273/Z/19/Z].”