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Weekly editorial curation of the top 1% most-discussed preprints.

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Αlpha1Science

The OS for working scientists.

New York · est. 2025

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© 2026 Αlpha¹ Science. All rights reserved.All systems operational
Weekly Preprint Curation

Alpha¹ Science

Editorial curation of the top 1% most-discussed bioRxiv preprints — with science context, social signal, and peer-review status.

Vol. 18 Issues Published2026ISSN Pending

This Week

Current issue

Current Issue
8
May 6, 2026
5 Articles
In This Issue
  1. 1Resolving human neuronal herpesvirus reactivation via petabase-scale association studies
  2. 2AI-guided discovery of atypical protein assemblies
  3. 3Cooling fast and slow: Characterising the effects of vitrification in cryo-EM...
  4. 4Polymer micelle model of transcriptional bursting
  5. +1 more article
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Perspectives

Editorials

EditorialApril 14, 2026

Traditional Paper Peer Reviews Are Delayed By Nature

Famed, pricey, and profitable journals no longer represent the frontier of science

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EditorialApril 1, 2026

Introducing Agent-Enabled Rigor Review on Alpha1Science

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Archive

Past issues

7 in archive

Issue
7
April 29, 2026
5 arts.
  1. Generative design of sequence specific DNA binding proteins
  2. Identification of a neural circuit that enables safe, long-term torpor in mice

+3 more

Read
Issue
6
April 21, 2026
6 arts.
  1. Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development
  • Whole-genome 3D architectural screen reveals modulators of brain DNA structure

    • +4 more

    Read
    Issue
    5
    April 14, 2026
    5 arts.
    1. Intranasal Anti-CD3 Antibody Treatment for Post-COVID Neuroinflammation
    2. GIFT: Scalable Genotyping in Fixed Transcriptomes for Clonal Heterogeneity

    +3 more

    Read
    Issue
    4
    April 8, 2026
    5 arts.
    1. OmicClaw: executable and reproducible natural-language multi-omics analysis over the unified OmicVerse ecosystem
    2. TRAILBLAZER: generative multicellular perturbation model of biology

    +3 more

    Read
    Issue
    3
    March 31, 2026
    5 arts.
    1. Transient contractility attenuation reprograms epithelial cells into a protrusion-driven state that drives tissue fluidization
    2. X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

    +3 more

    Read
    Issue
    2
    March 24, 2026
    6 arts.
    1. Behavioral, Physiological, and Transcriptional Mechanisms of Memory in a Synthetic Living Construct
    2. Towards building a World Model to simulate perturbation-induced cellular dynamics by AlphaCell

    +4 more

    Read
    Issue
    1
    March 20, 2026
    5 arts.
    1. Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism
    2. The Virtual Biotech: A Multi-Agent AI Framework for Therapeutic Discovery and Development

    +3 more

    Read